Eating Your Own Dog Food: WebDSL Case Studies to Improve Academic Workflows

SDF, Stratego and Spoofax provide a platform for development of domain-specific programming languages. On this platform, the WebDSL project started out as a case study in language engineering, and grew into a reliable tool for rapid prototyping and continuous development of web applications. Our team led by Eelco Visser develops and operates several web applications to support academic workflows. EvaTool governs the process of course quality control, importing questionnaire data, and providing lecturers and education directors with a platform to discuss and agree on improvements. WebLab is an online learning management system with a focus on programming education, with support for lab work and digital exams, used by over 40 courses. Conf Researchr is a domain-specific content management system for creating and hosting integrated websites for conferences with multiple co-located events, used by all ACM SIGPLAN and SIGSOFT conferences. MyStudyPlanning is an application for composition of individual study programs by students and verification of those programs by the exam board, used by multiple faculties at the Delft University of Technology. These tools served as practical case studies for applying the research, and ensure the continued development of the underlying platform

Conf Researchr: A Domain-Specific Content Management System for Managing Large Conference Websites

Conferences are great opportunities for sharing research, debating solutions, and networking. For the organizing committee there is a considerable deal of complexity and effort required to provide attendees and organizers with ways to find and manage programs, sessions, papers, tracks, talks, and authors. Eelco Visser found an opportunity to provide an integrated solution to these problems by designing the Conf Researchr conference management system in 2014 using our own domain-specific web programming language WebDSL. In this paper, we highlight the impact Eelco had on conference management, and how Conf Researchr evolved to become the platform of choice for hosting over 900 conference and workshop editions in SIGPLAN and SIGSOFT, among other areas of computer science research

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice